The American Dream is a traditional theme in American literature, therefore, the works of American writers tend to represent this proposition. Facing the changes at the turn of the century, from what he heard and saw, young Dreiser also wrote about the American Dream based on his own understanding in Sister Carrie. However, his opinion did not fall into the traditional cognitive pattern. Instead, the tendency of “reverse” in his opinion was very obvious. Of course, the meaning of “reverse” here is no longer “inversion” or “disorder” in the literal sense, but contains the realistic meaning of anti-traditionalism. In Sister Carrie, by “reversing” the three dimensions of gender, appeal and approach, Dreiser redefined the practical deviation in the connotation of the traditional American Dream. At the same time, the “reversed” action also reflects his protection of women's rights and interests in the “great turning era”, his affirmation of desire in the era of consumption and his advocacy of “fairness and morality” in the era of capital monopoly.