In the past, the entrepreneurial alertness studies focused on the discovery and identification of opportunities for entrepreneurs. However, in the corporate entrepreneurship context, there was a lack of in-depth study of how an organization was alert to the opportunities and threats in the internal and external environment and acted in a timely manner. Based on the theory of organizational learning 4I model, through a case study of key business decision-making of a new-retail chain of fashion enterprise, we found that: (1) the generation process of organizing alertness includes three key processes, multi-source attention, cross-layer interpretation and integrated judgment; (2) the effective convergence between different processes requires driving factors, including enterprise organization system and leader-member exchange. Based on the case study, this paper puts forward the model of organizational alertness in the corporate entrepreneurship decision-making. The model has theoretical guidance and practical significance for Chinese enterprises to pursue transformation and upgrading opportunities.