As six Departments of the National Health and Family Planning Commission enacted ‘The Notification of Implementing the Pilot Work on the Integrated Management of Mental Health’(National CDC，2015，No.57) in April 2015, that year has been seen as the first year of the coming of social work on mental health as well as the milestone of epoch-making and historical significance, marking that Chinese people need structural transformation and the development of health care system toward modernity. Mental health has become a national, universal and highest level of health needs. For the four decades since the reform and opening up, China has made remarkable achievements of policies and regulations on mental health, initially forming the system and framework of mental health policies and regulations with Chinese characteristics. However, social workers still stay in a “marginalized” position and cannot give their due profession to full play. The article first provides a succinct outline of the scope, contents and priorities of the framework and system with regard to mental health social work practices. Then the focus is to build China’s social work practical research agendas of mental health, to draw up a “list of practical research issues”of China’s social work on mental health, to designate the direction for future development of social work of mental health and to lay the foundation of social work for the full realization of the magnificent goal of the Healthy China and well-off society.