Abstract:“100 questions about Liu-Qiu” and “Q & A for Strange Diseases in Liu-Qiu” are both the diagnostic, medical, and prescription records made by emperor’s doctor, Lu Feng-Yi, based on the consultation he got from the famous doctor, Tsao Cun-Xin (1767—1834) under Wu school, regarding all the strange disease and diagnostic experiences Lu Feng-Yi had met with during his career. These records have now become precious information to observe the history of diseases and medicine in Liu-Qiu during the middle period of Qing Dynasty. Based on the earliest records about Liu-Qiu made by Chen Kan (1489—1538), he made the following statement regarding the physiques of local residents: “They need no medication there, and local residents also could stay healthy throughout their whole life; they don’t have chicken pox or measles problems until reaching their middle or elderly age”. Therefore, whether the local residents could always stay healthy or they didn’t really need any medication is a topic worthy of our further exploration. In this article, we could further examine the relationship between local diseases and social life based on the information obtained from “100 questions about Liu-Qiu”, and then verify the truthfulness of Chen Kan’s statement. Through the discussion made in this article, the diseases found in the local residents in Liu-Qiu had certain kind of generality (such as smallpox & syphilis) and regional characteristic (such as the root poison of a sago cycad). Apparently, “100 questions about Liu-Qiu” does reflect the life style and social status to quite a high level then and make itself a great comparison to records made based on precedent envoys own observation and probably biased viewpoints.