The influence of network space on traditional geographical space has attracted academic attention from the perspective of geography. The influence of online shopping on in-sore shopping has always been the focus of this research. Based on literature review and by introducing the concept of trading area with geographical meanings, this paper conducts the research of the influence of online shopping on in-store shopping from the angle of the trading area. Results show that online shopping has weak substitution effect on in-store shopping from the angle of online shopping attitude and obvious complementary effect from the angle of online shopping behavior, which confirms that substitution effect and complementary effect is coexistent. The main contribution of this paper is to study the influence of online shopping on in-store shopping from the perspective of the trading area with geographical meanings, substitution effect and complementary effect has been presented and portrayed in a geographical sense. The simultaneous existence of substitution effect and complementary effect have been confirmed in the geographical sense.