Abstract Using the analysis framework of new classical economics theory, this paper reveals the mutual influence mechanism and the path between endogenous comparative advantage, transaction efficiency and division of labor structure in international trade buyers and sellers. This study finds that the dynamic changes of the endogenous comparative advantage and transaction efficiency advantage is the root power of the evolution of the division of labor pattern of international trade. Meanwhile, the evolution of the division of labor pattern promotes the international trade mode through three stages, namely early bud, formation development and comprehensive development. It is more important that the process not only has the resource disposition effect, but also has an income distribution effect. The comprehensive role of endogenous comparative advantages and transaction efficiency is an effective path from hyper-markets gathering areas to global network goods centers, trade centers and information centers.
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